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The Institute of Neuropathology at the University of Giessen, Germany, Director Prof. Till Acker, invites applications for

1 Postdoc or PhD position in

PREDICTIVE MEDICINE IN NEUROONCOLOGY

The position is available immediately.

Your Profile:

We are looking for enthusiastic and highly motivated applicants holding, or about to obtain, a Master or PhD degree in Bioinformatics, Computational Biology, Medical Informatics or related areas. The candidates should have strong expertise in Python, combined with Machine- and Deep-Learning techniques. Experience in Docker and Linux is helpful. Preference will be given to applicants with previous experience in one or more of the following areas: use of cBioPortal and DataSHIELD, analysis of Whole- Slide-Images, DNA methylation- and/or NGS-data.

Topic:

The aim of the project is the development of novel AI-based algorithms within a team of biomedical informaticians that generate synergistic results from different data sources in a clinical study system to assist predictive medicine in translational cancer research. The initiative for a “Comprehensive Cancer Center (CCC) Hessen” provides the framework with a recently established system for conducting multicenter clinical studies. In this framework medical – in particular neurooncology - patient data from morphomolecular analyses (digital histopathology and genomics) and clinical metadata data are combined to develop precision diagnostics and predictive medicine approaches. The development of novel interface and interaction tools will also be part of the project.

What we offer:

Our international team offers an open, supportive, dynamic and motivating academic environment with excellent training opportunities with the possibility to work on cutting edge research projects. We have won a number of external research grants and are involved in several national and international collaborative projects. We use a wide spectrum of methods including DNA methylation array analysis, next generation sequencing, bioinformatic analysis, animal models and in vivo tumor models as well as tumor biopsies, immunohistochemistry, in situ hybridization, light, epifluorescence and confocal microscopy, image analysis. Our group has a longstanding expertise in the molecular, cellular and functional characterization of brain, lung and breast cancer development, with a special emphasis on microenvironmentand hypoxia-induced mechanisms in tumor biology.

The activity of the successful candidate will be integrated into the framework of the initiative for a “Comprehensive Cancer Center (CCC) Hessen” and MIRACUMConsortium (Medical Informatics in Research and Care in University Medicine, Vice-

Speaker: Prof. Till Acker; see also: miracum.org). In addition, collaboration possibilities and advanced training at the de.NBI (German Network for Bioinformatics

Infrastructure) as well as the newly founded University Center of BioMedical Informatics are available.

Please send your application as a single PDF: cover letter, your CV, certificates of your qualifications, your publication list and the contact details of at least two referees until 15.04.2021 to our lead bioinformatician Daniel Amsel (Daniel.Amsel at patho.med.uni-giessen.de).

Applicants with disabilities but otherwise equal qualifications will be preferred.

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