ISCB Affiliated Group Logo

The Pediatric Oncology Reseach Institute of the Department of Pediatric Hematology, Oncology and SCT at the Charité – Universitätsmedizin Berlin is a multidisciplinary research institute closely affiliated to the Helmholtz Institute, Max Delbrück Center for Molecular Medicine (MDC) and the Berlin Institute of Health (BIH).

The goals of the research group of Prof. Johannes Schulte are an improved understanding of tumor biology and development of new therapeutic options for neuroblastoma, a highly devastating childhood cancer.

Investigating primary and relapse tumors as well as tumor model systems, we seek to identify key factors of tumor pathogenesis, tumor progression and tumor evolution. The research strategy of our interdisciplinary team includes multi-omics and wet lab approaches. Concepts identified in high-throughput analyses are validated in vitro and in vivo. To this end, we use cell culture model systems, patient-derived tumor xenografts and genetically engineered mouse models. Furthermore, we participate in major European Systems Biology consortia for generating and analyzing high-throughput sequencing data.

We are looking for a computational biologist / bioinformatician to develop and apply new analytical approaches for the study of neuroblastoma genomics. This research position is embedded into an interdisciplinary team of clinicians, biologists, biotechnologists and bioinformaticians and into the dynamic intellectual environment of the Charité and the BIH. The successful applicant will 1) set up analytical pipelines for diagnostic targeted resequencing, 2) plan and perform analyses within neuroblastoma research projects, 3) structure and manage high-throughput data 4) support existing collaborations with other bioinformatics groups (e.g. Nils Blüthgen, Uwe Ohler, Altuna Akalin, Dieter Beule). In collaboration with these groups, the applicant will be able to pursue his/her own bioinformatics research projects.

Prerequisites

The ideal candidate has a Master's (MSc) or PhD degree in computer science, computational biology, bioinformatics, statistics or any other quantitative discipline and proven experience in the analysis of next-generation sequencing data.

Moreover, the candidate should have excellent programming skills for data analysis, preferably in R, and be familiar with Bash scripting and one other scripting language such as Perl/Python. In-depth knowledge of applied multivariate statistics and data visualization techniques are also required.

An advanced knowledge of tumor biology and a publication track record of genomics-based oncology research are highly desirable.

Excellent communication and project management skills as well as the motivation for a long-time commitment in our department are a requirement.

Conditions

The position is open from August 2017. Salary will be according to the Charité internal tariff TV-C E13 with regular working time of 39 h per week. The initial contract will be until 31st of July, 2019 with the option of extension depending on extramural funding resources. The Charité – Universitätsmedizin Berlin is an equal opportunity employer and supports gender equality. Persons with disabilities will be preferred if equally qualified. The Charité cannot reimburse any incurring travel expenses.

Please, submit your application by email, including a cover letter describing your interests, a current CV, and 2-3 letters of recommendation, by August 13, 2017, to Prof. Johannes Schulte and Dr. Joern Toedling (Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein! and Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!) and indicate the registration number DM.127.17.