On a project funded by the European Research Council (ERC) we are recruiting
one postdoc and two PhD students with background in bioinformatics, computational biology, data science, or engineering.
The goal of the project is to identify determinants of resistance to immunotherapy and develop personalized in silico and in vitro models for predicting responses to combination therapy in colorectal cancer. Towards this goal we are systematically interrogating tumor-immune cell interactions using data-driven modeling and knowledge-based mechanistic modeling, and are generating key quantitative data to train and validate algorithms using perturbation experiments with patient-derived tumor organoids and cutting-edge technologies for multidimensional profiling. The candidates will analyze next-generation sequencing data, phosphoproteomics data, and metabolomics data from tracer studies, and investigate rewiring of signaling networks and metabolic reprograming of T cells. The anticipated outcome is a precision immuno-oncology platform that integrates tumor organoids with high-throughput and high-content data for testing drug combinations, and machine learning for making therapeutic recommendations for individual patients.
The Division of Bioinformatics (www.icbi.at) is at the Biocenter of the Medical University of Innsbruck, Austria (www.i-med.ac.at)
Innsbruck (Capital of the Alps, www.innsbruck.info): Doing science where others spend their vacation.