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The Institute of Computational Biology is globally recognized for innovations in data analysis and modeling of biological systems, anchored at the Helmholtz Zentrum Munich and the Technical University Munich.

For our research team "Translational Immunogenetics" we are currently looking for a

PhD Candidate for the Project: "Effects of Non-Conventional Epitopes in Type 1 Diabetes"(E13 TV-L)

Job Description

The Ph.D. project will focus on studying the effects of non-conventional epitopes on type 1 diabetes progression and their potential therapeutic exploitation.

The aims of the projects involve:

Developing bioinformatics pipelines to identify non-conventional epitopes derived from alternative splice forms, fusion proteins, and post-translational modifications

Developing predictive models to estimate the effect of post-translational modifications on HLA-epitope affinity

Investigating the prevalence and impact of non-conventional epitopes on disease progression and their interplay with the T-cell population

Developing optimization models for computer-aided vaccine design for type 1 diabetes

 

Your Qualifications

Master’s Degree in Bioinformatics, Biostatistics, Informatics or related fields (with significant experience in Bioinformatics)

Experience with NGS (transcriptomic and genomic) analysis

Experience in machine learning

Excellent programming skills (R, Python, C/C++)

Scientific curiosity and ability to work independently

Highly motivated to work in a young and multi-disciplinary, collaborative environment

Fluent in spoken and written English

 

The following qualifications are considered advantageous:

Basic understanding of the immune system

Know How in combinatorial optimization

 

Our Offer

At the Helmholtz Zentrum München, you can contribute together with leading researchers to the investigation of the development, prevention, and treatment of environmental diseases such as diabetes, chronic lung diseases, and allergies. To further promote your professional development, we offer extensive and targeted research training and career programmes. We support the reconciliation between work and private life with flexible working time models, occupational health management, day care facility for children, a childcare subsidy, Elder Care, as well as other counseling and support services.

Remuneration and benefits are following the collective agreement for the public service (EG 13 50% TV EntgO Bund). Also, there is also the possibility of granting an allowance amounting to 15% if the necessary conditions are fulfilled.

The position is (initially) limited to three years.

The activity involves specialized knowledge and experiences specific to own scientific skills.

As a holder of the Total E-Quality Award, we promote equality of opportunity. Applications from women are welcome. Qualified applicants with physical disabilities will be given preference.

Please apply through our online application system with a motivation letter, curriculum vitae, transcripts and certificates, and contact details of two academic references.

 

 Apply now: https://fragebogen.candibase.de/helmholtz/mainform.php?param=627807ce092170db5005d4c6df6be3b8&lang=en