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The Institute of Computational Biology is globally recognized for innovations in data analysis and modeling of biological systems, anchored at the Helmholtz Zentrum Munich and the Technical University Munich.

For our research team "Translational Immunoinformatics" we are currently looking for a

PhD Candidate for the Project: "Cell Fate Modeling in Chronic Lung Diseases” (E13 TV-L)

Job Description

The Ph.D. project will focus on the characterization of genetic factors describing pulmonary fibroblasts in chronic lung diseases and the identification of transcriptional factors that can be used to reprogram diseased lung fibroblasts to healthy lung epithelial cells.

 

The aims of the projects involve:

Identifying biomarkers that lead to fibroblast formation in the lung for early risk assessment

Developing a risk prediction model using the identified biomarkers

Modeling longitudinal mass cytometry data to describe the reprogramming path of fibroblasts to epithelial cells

Analyzing and integrating simultaneously collected single-cell RNA-seq data

 

The Ph.D. candidate will have the opportunity to be integrated into the experimental partner lab to help develop novel analytical strategies in direct interaction with the members of the experimental lab.

 

 Your Qualifications

 

A Master’s Degree in Biostatistics, Bioinformatics, Statistics or related fields (with significant experience in Bioinformatics)

Experience in multivariate statistics and Bayesian modeling

Excellent programming skills (R, Python, C/C++)

Scientific curiosity and ability to work independently

Highly motivated to work in a young and multi-disciplinary, collaborative environment

Fluent in spoken and written English

 

The following qualifications are considered advantageous:

 

Experience with NGS (transcriptomic and genomic) analysis

Basic understanding of mass cytometry analysis

Basic understanding of single-cell RNA-Seq analysis

 

Our Offer

 

At the Helmholtz Zentrum München, you can contribute together with leading researchers to the investigation of the development, prevention, and treatment of environmental diseases such as diabetes, chronic lung diseases, and allergies. To further promote your professional development, we offer extensive and targeted research training and career programmes. We support the reconciliation between work and private life with flexible working time models, occupational health management, day care facility for children, a childcare subsidy, Elder Care, as well as other counseling and support services.

Remuneration and benefits are following the collective agreement for the public service (EG 13 50% TV EntgO Bund). Also, there is also the possibility of granting an allowance amounting to 15% if the necessary conditions are fulfilled.

The position is (initially) limited to three years.

The activity involves specialized knowledge and experiences specific to own scientific skills.

As a holder of the Total E-Quality Award, we promote equality of opportunity. Applications from women are welcome. Qualified applicants with physical disabilities will be given preference.

Please apply through our online application system with a motivation letter, curriculum vitae, transcripts and certificates, and contact details of two academic references.

Apply now: https://fragebogen.candibase.de/helmholtz/mainform.php?param=28723aca288cb003ca4914689782604a&lang=en