- Veröffentlicht: Freitag, 05. Februar 2021 08:58
The project aims at linking phenotypic adaptations to genomic differences, which is a central goal in the genomics era. The postdoc is expected to capitalize on a powerful repertoire of genomic methods as well as genome alignments and comparative data for several hundred mammals and birds that the lab has generated. A large list of interesting adaptations including metabolic, physiological and morphological traits in bats, dolphins, other mammals and vertebrates is available to be studied, and choices can be influenced by the preference of the postdoc.
The mission of our group is to understand how nature's fascinating phenotypic diversity has evolved and how it is encoded in the genome. Work in the lab includes genome sequencing and assembly, genome alignment and annotation, development and application of comparative genomic methods to discover differences in genes and cis-regulatory elements, and the use of statistical approaches to link phenotypic to genomic changes [1-8].
Our lab is part of TBG (https://tbg.senckenberg.de/) and Senckenberg Research Society, and is based near the city center of Frankfurt am Main, Germany. The TBG provides access to cutting-edge computational infrastructure (HPC, genome browser) and lab facilities to sequence genomes of diverse creatures. English is the working language in our lab. Frankfurt is a vibrant and highly-international city at the heart of Europe that combines a skyscraper skyline with ample park and green areas.
Applicants should have a degree in bioinformatics/computational biology, genomics or a related area, and a strong publication record. Solid programming skills in a Linux environment and experience with shell scripting and Unix tools are required. Previous experience in large-scale comparative genomic data analysis is an advantage.
How to apply:
If interested, please email (i) your CV including publication list and contact information for at least two references and (ii) a summary of previous research experience (max 1 page) to Michael Hiller (Michael.Hiller@senckenberg.de). Further information: https://tbg.senckenberg.de/personen/hiller/
The position is fully-funded. Salary and benefits are according to TV-H E13 100%. The position will be initially for 2 years, but funding is available to extend it further. The employer is the Senckenberg Society for Nature Research in Frankfurt am Main. Senckenberg supports equal opportunity of men and women and therefore strongly invites women to apply. Equally qualified handicapped applicants will be given preference.
Application deadline is March 15th 2021. The position is available immediately and the search continues until the position has been filled.
 Jebb et al. Six reference-quality genomes reveal evolution of bat adaptations. Nature, 583, 578–584, 2020
 Huelsmann et al. Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations. Science Adv, 5(9), eaaw6671, 2019
 Hecker et al. Convergent gene losses illuminate metabolic and physiological changes in herbivores and carnivores. PNAS, 116(8), 3036-3041, 2019
 Roscito et al. Phenotype loss is associated with widespread divergence of the gene regulatory landscape in evolution. Nature Communications, 9:4737, 2018
 Langer et al. REforge associates transcription factor binding site divergence in regulatory elements with phenotypic differences between species. MBE, 35(12), 3027–3040, 2018
 Lee et al. Molecular parallelism in fast-twitch muscle proteins in echolocating mammals. Science Adv, 4(9), eaat9660, 2018
 Sharma et al. A genomics approach reveals insights into the importance of gene losses for mammalian adaptations. Nature Communications, 9(1), 1215, 2018
 Nowoshilow et al. The axolotl genome and the evolution of key tissue formation regulators. Nature, 554(7690), 50-55, 2018