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Stellenangebote

Bioinformatician (f/m/d) [Cardio-CARE research group, Medizincampus Davos, Switzerland]

 

The Cardio-CARE research group, Medizincampus Davos, Switzerland, funded by the Kühne Foundation, is searching for one highly motivated

Bioinformatician (f/m/d)

for ambitious collaborative projects in cardiovascular disease. In the largest ongoing project, 9000 subjects from the Hamburg City Health Study are undergoing whole genome sequencing at the University Hospital Zurich until summer 2021. All data analysis will be done at Cardio-CARE in Davos in close collaboration with the Department of Cardiology from the University Medical Center in Hamburg, Germany.

What Is Special About Davos?

Davos is the largest resort in the Alps for mountain holidays and sport. It is at 1560 m the highest town in the Alps and has one of Switzerland’s biggest ski resorts. In winter you can enjoy more than 300 km of slopes, and in summer explore 700 km of hiking trails. Davos is also the traditional host of the World Economic Forum.

What Would Be Your Main Responsibilities?

• You perform the complete bioinformatics analysis, starting from FASTQ files to annotated joint called VCF files • You perform data analysis, integration and visualization
• You participate in maintaining and administering the High Performance Computing (HPC) cluster
• You provide training and support in programming and bioinformatics to team members

• You participate in the publication of research findings

Why We Want You To Join Our Team?

• You have a background in Bioinformatics, Computational Biology, Computer Science or similar
• You are experienced in next-generation sequencing data analysis and have good working knowledge of standard bioinformatics tools, such as GATK or samtools
• You are familiar with GNU/Linux environments and HPCs
• You are proficient in R, including RMarkdown, Knitr and Shiny
• You are familiar with one or more programming languages, such as C/C++, Python or Java
• You have hands-on experience of reproducible workflows and version control
• You might have additional skills, such as a good understanding of molecular or cell biology, machine learning or Bayesian statistics
• You love to communicate, to collaborate, to connect different scientific disciplines and to contribute to multidisciplinary teams

Why You Want To Join Our Team?

• You want to be an important researcher who plays a critical role in expanding a research infrastructure • You want to pursue meaningful international research projects at the highest level
• You value our many possibilities for personal and professional growth
• You value quality of life and the opportunity to work in a magnificent scenery

• We are happy to provide help in terms of relocation procedures

Interested?

We look forward to receiving your application with a brief explanation why you are the ideal candidate for this position, your detailed curriculum vitae and contact details of 2-3 referees. Your application should be sent as a single pdf file containing all of your application documents to Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!. Questions regarding the positions should be directed to Prof. Dr. Andreas Ziegler, phone: +49 175 8081883. Initial application deadline is January 31, 2021 but the call will remain open until the positions are filled. Candidates will be contacted by us on a rolling basis.

Due to Swiss immigration regulations, priority will be given to applicants holding a Swiss passport, a valid Swiss working permit or EU/EFTA passport.

 

PhD pos., Comp. biochem./chem. or struct. bioinf., U of Duesseldorf, Gohlke group

We invite applications for one PhD student position in the Computational Pharmaceutical Chemistry & Molecular Bioinformatics group (Prof. Dr. Holger Gohlke) at the Heinrich-Heine-University, Duesseldorf, Germany.

Topic

Functional state modulation of membrane proteins by dynamic association and dissociation.

Background

Find more detailed information regarding this position here or under:

https://cpclab.uni-duesseldorf.de/index.php/Openings

Availability

The position is available immediately.

Requirements
Ideal candidates will have a record of excellence and a strong background in computational biochemistry/chemistry or structural bioinformatics, a high interest in working in an interdisciplinary collaboration, and profound knowledge in state-of-the-art molecular dynamics simulations (Amber) software, molecular modelling (in particular, protein-protein docking), and QM/MM calculations.

Application process

Applicants should submit applications (a one-page letter of motivation why they are interested in the respective project and how they can contribute to the project’s success, a current CV, and contact data of three references) by email to gohlke[at]uni-duesseldorf.de . Please provide all documents as one PDF file and specify for which position you are applying.

PhD student „Computational biology of ctDNA“ (m/f/d)

We are looking for committed people with enthusiasm for biomedical research!

TRON gGmbH – Translational Oncology at the Medical Center of the University Mainz – is a non-university, biopharmaceutical research institute in the legal form of a non-profit organization. The company’s aim is to develop highly innovative technologies to address medical needs in the fields of cancer diagnostics and therapeutics. TRON was founded in Mainz in 2010 and works in close cooperation with universities and clinics as well as with regional, national and international research institutions and companies in the pharmaceutical industry.

As part of our team, you have the opportunity to work with talented and dedicated colleagues, to develop and expand your professional experience, and to be at the cutting-edge of translational science to improve patient lives.

TRON is currently expanding its multidisciplinary Computational Medicine Unit with exceptional experience in next generation sequencing data analysis and immuno-informatics. One of our projects focuses on circulating tumor DNA (ctDNA). CtDNA is fragmented DNA derived from tumors and circulates in the bloodstream. Analyzing ctDNA enables early cancer detection, molecular profiling, treatment monitoring and to study tumor evolution. A key challenge is the sensitive computational identification of tumor specific mutations from sequencing data of plasma samples. In order to enlarge our technological knowledge and expertise, we are searching for a

PhD student „Computational biology of ctDNA“ (m/f/d)

DUTIES AND RESPONSIBILITIES

·         Design efficient sequencing and analysis strategies for ctDNA

·         Implement best-in-class software solutions for highly accurate data analysis

·         Design experiments for confirmation of computed findings

·         Analyze time series data from clinical studies

·         Tight interaction with genomics and molecular biology teams

QUALIFICATION AND EXPERIENCE

·         Master-level education in bioinformatics, computer science or a related field

·         Deep understanding of cancer biology and immunology is a plus

Any experience in NGS data analysis and programming as well as in in machine learning completes your profile.

If you are a self-starter who loves working effectively in an agile start-up environment, and besides if you do have strong visual, verbal and written communication skills, you will feel well and home at TRON and within your task. If you are additionally an enthusiastic team player who is thrilled by supporting the implementation of personalized medicine, you should not wait any longer to apply for this position.

We look forward to receiving your application.

Please send your application documents (cover letter, CV, certificates) in one document of max. 5 MB by email to Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein! to the attention of Sandra Nauth, reference “PhD ctDNA”.

For further information please visit our homepage www.tron-mainz.de

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