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The Schulte lab at the Charité Virchow campus in Berlin is looking for a dedicated bioinformatics student to join us in spring/summer 2017 for the research project

Identifying circRNAs in Neuroblastoma

Scientific background
Circular RNAs (circRNAs) have been found to make up a relevant proportion of spliced transcripts from coding and non-coding genes [1], yet the function of the vast majority of circRNAs is still unclear.Neuroblastoma is the most common extra-cranial solid tumour in childhood. As neuroblastoma is marked by extremely few coding mutations, other defects in the regulatory program of cell proliferation and differentiation can be suspected, potentially involving epigenetics and non-coding RNAs.

Schulte lab
In the Schulte lab at Charité, we use genomics and wet-lab experiments to gain new insights into neuroblastoma. The group consists of physicians, molecular biologists and bioinformaticians working together towards an increased understanding of tumour development.

Project description
The student will develop algorithms for identifying circRNAs from RNA-Seq data and contribute to computational tools for functional annotation of circRNAs. The student will be based at the Charité Virchow campus as part of the interdisciplinary project team and mainly supervised by Dr. Joern Toedling. The project lends itself to becoming a master’s or diploma thesis, in which case it will be reviewed by Professor Schulte (Charité) and a second reviewer from the student’s home university, to be suggested by the student. In case the methods developed by the master student or any of her/his findings are going to be used in a publication, the student will be credited with a co-authorship on that publication. The project is a collaboration between our group at the Charité and Professor Rajewsky (MDC Berlin).

Requirements
A strong interest in non-coding RNAs and some knowledge of next-generation sequencing data processing are required. The student should arrange for staying at least 3 to 6 months full-time in our lab in Berlin.

How to apply?
Please send applications, as well as informal requests, to This email address is being protected from spambots. You need JavaScript enabled to view it..

References
[1]Szabo L, Salzmann J. Detecting circular RNAs: bioinformatic and experimental challenges. Nature Reviews Genetics, November 2016.
[2]Schulte lab: https://paedonko.charite.de/en/research/schulte_lab

 

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