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The Institute for Computational Genomics, RWTH Aachen University
performs cutting edge research on computational and genomic methods
for understanding regulatory and epigenetic processes driving cell
differentiation and diseases (Gusmao, Nature Methods, 2016, Li, Genome
Biology, 2019). This project aims studying RNA-DNA interactions as
mechanisms of transcriptional control. We have recently shown how
long-noncoding RNAs (HOTAIR, GATA6-AS, NEAT1) interacts with DNA via
triple helices to control the expression of genes during cell
differentiation (Kalwa et al., NAR, 2016; Kuo, NAR, 2019; Frank, Cell
Stem cell, 2019).

We are looking for a phd/postdoc candidate to work on sequence
analysis algorithms and statistical models for detection of RNA-DNA
triple helices. This includes the analysis of novel in vitro
transcription experiments and target sequencing protocols, which
capture triple helix forming RNA and DNA molecules. This project will
be performed in collaboration with cell biologists of RWTH Aachen,
University of Cologne and University of Oslo.

Applicants should hold a M.Sc. or Ph.D. in Bioinformatics or Computer
Science. Experience in the analysis of biological sequences and
regulatory genomics is required. The candidate should have solid
programming skills (C, Python and/or R) and acquaintance with
Unix/Linux. Experience with high performance computing is a plus. The
working language of the group is English. The position is a will be
initially for 3 years with possibility of extension. The salary
corresponds to level 13 TV-L.

Interested candidates should send a brief statement of research
interests, CV and the names of three references to This email address is being protected from spambots. You need JavaScript enabled to view it..
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